Magnesium - In patients with fibromyaliga, magnesium levels are often found to be low or deficient when compared with subjects who do not have symptoms of fibromyalgia (1). Some patients may show normal serum levels of magnesium, but intracellular levels are often deficient (2). A blend of intravenously injected vitamins and minerals, called a Myer’s Cocktail, containing high amounts of magnesium has resulted in decreased and even complete resolution of fibromylagia symptoms (3). IM and IV Magnesium given alone have demonstrated effectiveness in reducing chronic muscle complaints (4).

Ascorbigen and Broccoli Powder - Ascorbigen is one of the most common medicinal compounds, called indoles, released when cruciferous vegetables are cooked. These types of indoles can induce Phase I detoxification in the liver (5). A clinical trial was conducted at National College of Naturopathic Medicine in Portland, Oregon where patients with fibromyalgia were given both 100 mg of ascorbigen powder and 400 mg of broccoli powder for one month. Patients experienced a significant reduction in both physical impairment and total fibromylagia impact scores (6).

Rhodiola rosea Extract - Rhodiola is a medicinal plant that is used clinically to treat functional fatigue and mild cognitive decline. The compounds in this plant have been shown to increase ATP production (7). This is particularly helpful in fibromyalgia because ATP availability is important for working muscle and preventing fatigue.

Ginger root Extract - Ginger is an herb with a long history of use throughout Asia and ancient Greece for rheumatic disorders. A clinical trial of patients with rheumatoid arthritis, osteoarthritis and muscular discomfort demonstrated relief of pain with dried ginger consumption in all patients with muscle pain (8). As well case histories from patients with rheumatoid arthritis who have used ginger as an adjunct treatment cite additional relief over conventional medication alone (9).

5-HTP - A number of clinical studies have examined the role of serotonin and the precursor, 5-HTP, in patients with fibromylagia. One clinical trial involved a 90 day trial of supplementation with 5-HTP in patients with fibromyalgia. Nearly 50% of patients investigators noted a good or fair clinical improvement in symptoms such as number of tender points, anxiety, pain intensity, quality of sleep and fatigue (10). Another double blind placebo controlled trial also showed that all clinical parameters studied were significantly improved by treatment with 5-HTP when compared to placebo (11).

Melatonin - Melatonin is a naturally produced biochemical that is secreted from the pineal gland at the base of the brain, which controls circadian rhythms and plays a major role in sleep cycles. Numerous studies have shown a link between melatonin levels in patients with fibromyalgia. Typically patients with fibromyalgia have lowered secretion of melatonin at night, which may partially explain impaired sleep at night, fatigue during the day, and changed pain perception (12).A clinical trial demonstrated that supplementation at bedtime with melatonin can significantly improve tender point count, severity of pain and sleep (13).

Malic Acid - Malic acid is a naturally occurring chemical found most notably in apple juice. It helps improve absorption of some nutrients like magnesium. A randomized double blind placebo controlled trial showed that supplementation with a proprietary tablet of malic acid and magnesium, given at a high dose over 6 months resulted in significant reductions in the severity of all 3 primary pain/tenderness measures without adverse effects (14).

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